130 Pattern of Antibiotic Therapy and Effectiveness in Gastrointestinal surgeries

Thursday, May 19, 2016
Mr. Santosh Chandrashekar, Doctor of Pharmacy1, Mr. Ibel C Fredy, Doctor of Pharmacy1 and Mr. Srinivasan Ranganathan, M.Pharm.(PhD)2
1College of Pharmacy, PES College of Pharmacy, Bangalore, India
2Department of pharmacy, Annamalai University, Annamalai nager, India
Introduction:

Surgical site infection is one of the most common healthcare-associated infection in patients undergoing sur­gery and remains a major source for post-operative morbidity. This encourages surgeons to adopt a more liberal approach toward prescribing antibiotics. In practice this may seem beneficial in reducing infection rates in inpatient setting, but can potentially lead to emergence of more resistant microorganisms. Thus, resulting in worsening of patient condition as well as increased health-care costs. Appropriate antibiotic prescribing for the purpose of prophylaxis as well as post-operative purpose in surgical units is of great importance. Ensuring improved quality of care for patient, infection control as well as to prevent proliferation of multi-resistant organisms.

Objectives:

The purpose of the study is to identify the pattern of antibiotic usage as prophylactic or infection control in various GI surgeries and its effectiveness.

Study Design:

Cross sectional Retrospective study  

Methods:

  1. Cross-sectional Retrospective study conducted at quaternary care hospital (Jan 2015 - Dec 2015)
  2. Data was collected as case series and analyzed using Microsoft excel.
  3. Appropriateness of antibiotic therapy was based on compliance with ASHP Therapeutic Guidelines

Results:

Over the study period, a total of 652 patient profiles were collected. Surgical procedures performed were appendectomy (45, 6.90%), gastroduodenale procedures (141, 21.66%), laparoscopic procedures (104, 15.97%), small intestine obstruction removal (23, 3.53%), hernia repair (86, 13.21%), colorectal procedures (150, 23.04%), cancer surgery (38, 5.84%), hepatic surgeries (31, 4.75%) and other (33, 5.10%). The antibiotic therapy for the above procedures was compared with American Society of Health-System Pharmacists therapeutic guidelines.

Conclusions:

Analysis for the appropriateness of antibiotic therapy in compliance with ASHP Therapeutic guidelines is currently under process.